Cas 103041-38-9,3-(Pyridin-2-ylaMino)-Propionic Acid Ethyl Ester
| Payment Type: | L/C,T/T |
|---|---|
| Terms of Trade: | FOB |
| Min. Order: | 1 Kilogram |
| Delivery Time: | 15 Days |
| Packaging: | AS REQUIRED |
|---|---|
| Productivity: | KGS |
| Brand: | VOLSENCHEM |
| Transportation: | Air |
| Place of Origin: | CHINA |
| Supply Ability: | 100KG |
| Certificate: | ISO |
Basic Info
Model No.: 103041-38-9
Product Description
Dabigatran etexilate intermediate with the chemical name of 3-(Pyridin-2-ylaMino)-propionic acid ethyl ester CAS number 103041-38-9,Exactly speaking,it is the side chain of the intermediate of dabigatran etexilate in the fifth step. The appearance is off-white to white powder. Its usually produces the fifth step intermediate of dabigatran etexilate by reaction with 3-bromo-4- (methylamino) benzoic acid,details as follows: 34.4 g of 3-bromo-4- (methylamino),mixed with 240 mL of dichloromethane at room temperature and stirred for 1 hour and cooled to -20 ° C. 12.0 mL of thionyl chloride was added and then about 0.5 mL of N, N-dimethylformamide was added dropwise to continue the reaction for 4 hours. Until naturally rising to room temperature, then 29.12gram of ethyl 3- (pyridin-2-ylamino) propionate , 41.7ml were added, continued reaction for 6 hours at room temperature, the reaction was terminated by adding 300 mL of water, the organic layer was separated, The mixture was further washed with 200 mL of saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to a total volume of about 100 mL. 50 mL of n-hexane was added to precipitate a solid which was stirred for 2.5 hours at room temperature. Vacumn Dried for 1 hour to give a white solid 57.7 g, this white solid was dabigatran etexilate intermediate N-5.
Thera. Category: Antithrombotic/Blood thinners
Cas No.:103041-38-9
Synonym:ethyl (2S)-2-[(pyridin-2-yl)aMino]propanoate;3-(Pyridin-2-ylaMino)-propionic acid ethyl ester;Ethyl 3-(2-PyridylaMino)propanoate;N-Ethyl 3-(pyridin-2-ylaMino)propanoate;N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl ester;
Molecular Weight:194.23036
Molecular formula:C10H14N2O2
Purity: ≥99.%
Appearance: White Crystalline solid
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Usage: It can treat and prevent blood clots, reducing the risk of stroke.
Related intermediate:
CAS
Chemical Name Specification Color 41263-74-5 4-(MethylaMino)-3-nitrobenzoic acid HPLC ≥99.0% pale brown 103041-38-9 N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER HPLC ≥99.0% off white to white 429659-01-8 ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE HPLC ≥99.0% orange yellow solid 42288-26-6
N-(4-CYANO-PHENYL)-GLYCINE HPLC ≥99.0% off white Loss on drying ≤1.0% 212322-56-0
3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HPLC ≥99.0% off white Melting point 101.0°C~106.0°C Single impurity ≤0.3% Loss on drying ≤0.5% Residue on ignition ≤0.5% Assay ≥98.0% 211915-84-3
Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester HPLC ≥99.0% off white Single impurity ≤0.3% Loss on drying ≤0.5% Residue on ignition ≤0.5% Assay ≥99.0% 872728-85-3 N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate HPLC ≥97.0% off white 211915-06-9
Dabigatran Etexilate HPLC ≥98.0% white Single impurity ≤0.2% Loss on drying ≤1.0% Assay ≥98.0% 872728-81-9
Dabigatran etexilate mesylate HPLC ≥99.0% light yellow solid Single impurity ≤0.5% Loss on drying ≤1.0% Residue on ignition ≤0.1% Heavy melta ≤20 ppm Assay ≥98.5%
Taizhou Volsen Chemical Co., Ltd. is professional in R&D, producing and marketing Pharmaceutical raw materials, pharmaceutical intermediates in China. VOLSEN consists of about 100 experienced employees including 3 PhD and 10 Master, and 35000 sqm facilities including research laboratories, kilo lab, pilot plant and full manufacturing plant,
VOLSEN R&D specialists, quality manager and sales with abundance experience make sure products are reliable and service is professional. The producing person inspect every step of the whole process and check up the quality strictly, in order to insure every batch of raw material achieve the standard of EP,CP, JP,BP etc.Matching to the diversified requirements of companies VOLSEN is steadily marching to reach the peaks.
Volsen owns a professional custom synthesis department, with more than 15 senior scientific research chemical personnels who have a graduate degree or above. We also have an independent scientific management system. Our company integrates years of production experiences and talent reserves that forms a strong R&D production capacity, furthermore we could undertake various chemicals customizations from kg to ton relying on the existing production base and equipment.
Manufacturing Unit is equipped with a facility of progressive reeducation of emissions, effluents and discharge of waste material that are known to have a negative impact on the environment. Besides, Laboratory as well as plant is equipped with latest Machinery, Equipments, Technical personnel & Means of communications.
Due to supply of reliable quality, efficient follow up, scheduled delivery and prompt response to any matter, company wins good comments from customers.
We aimed at delivering real business value to our clients. For any interest, pls call on us or email us to get our best services.
Company Info
- Company Name: Taizhou Volsen Chemical Co., Ltd.
- Representative: Mr Chen
- Product/Service: Efinaconazole Intermediates , Isavuconazole Intermediates , Obeticholic Acid Intermediates , Vilanterol Intermediates , Dolutegravir Intermediates , Umeclidinium Bromide
- Capital (Million US $): 60000000RMB
- Year Established: 2002
- Total Annual Sales Volume (Million US $): Above US$100 Million
- Export Percentage: 91% - 100%
- Total Annual Purchase Volume (Million US $): Below US$1 Million
- No. of Production Lines: 5
- No. of R&D Staff: 91 -100 People
- No. of QC Staff: 11 -20 People
- OEM Services Provided: yes
- Factory Size (Sq.meters): 30,000-50,000 square meters
- Factory Location: Dongying Economic Development Zone , Dongying, Shandong,China
- Contact Person: Ms. Amy Cheng
- Tel: 86-576-88869393
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