Cas 103041-38-9,3-(Pyridin-2-ylaMino)-Propionic Acid Ethyl Ester
|Terms of Trade:||FOB|
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
|Place of Origin:||CHINA|
Model No.: 103041-38-9
Dabigatran etexilate intermediate with the chemical name of 3-(Pyridin-2-ylaMino)-propionic acid ethyl ester CAS number 103041-38-9,Exactly speaking,it is the side chain of the intermediate of dabigatran etexilate in the fifth step. The appearance is off-white to white powder. Its usually produces the fifth step intermediate of dabigatran etexilate by reaction with 3-bromo-4- (methylamino) benzoic acid,details as follows: 34.4 g of 3-bromo-4- (methylamino),mixed with 240 mL of dichloromethane at room temperature and stirred for 1 hour and cooled to -20 ° C. 12.0 mL of thionyl chloride was added and then about 0.5 mL of N, N-dimethylformamide was added dropwise to continue the reaction for 4 hours. Until naturally rising to room temperature, then 29.12gram of ethyl 3- (pyridin-2-ylamino) propionate , 41.7ml were added, continued reaction for 6 hours at room temperature, the reaction was terminated by adding 300 mL of water, the organic layer was separated, The mixture was further washed with 200 mL of saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to a total volume of about 100 mL. 50 mL of n-hexane was added to precipitate a solid which was stirred for 2.5 hours at room temperature. Vacumn Dried for 1 hour to give a white solid 57.7 g, this white solid was dabigatran etexilate intermediate N-5.
Thera. Category: Antithrombotic/Blood thinners
Synonym:ethyl (2S)-2-[(pyridin-2-yl)aMino]propanoate;3-(Pyridin-2-ylaMino)-propionic acid ethyl ester;Ethyl 3-(2-PyridylaMino)propanoate;N-Ethyl 3-(pyridin-2-ylaMino)propanoate;N-PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl ester;
Appearance: White Crystalline solid
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Usage: It can treat and prevent blood clots, reducing the risk of stroke.
Chemical Name Specification Color 41263-74-5 4-(MethylaMino)-3-nitrobenzoic acid HPLC ≥99.0% pale brown 103041-38-9 N-PYRIDYL-B-ALANIN-ETHYL ESTER HPLC ≥99.0% off white to white 429659-01-8 ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE HPLC ≥99.0% orange yellow solid 42288-26-6
N-(4-CYANO-PHENYL)-GLYCINE HPLC ≥99.0% off white Loss on drying ≤1.0% 212322-56-0
3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HPLC ≥99.0% off white Melting point 101.0°C~106.0°C Single impurity ≤0.3% Loss on drying ≤0.5% Residue on ignition ≤0.5% Assay ≥98.0% 211915-84-3
Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester HPLC ≥99.0% off white Single impurity ≤0.3% Loss on drying ≤0.5% Residue on ignition ≤0.5% Assay ≥99.0% 872728-85-3 N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate HPLC ≥97.0% off white 211915-06-9
Dabigatran Etexilate HPLC ≥98.0% white Single impurity ≤0.2% Loss on drying ≤1.0% Assay ≥98.0% 872728-81-9
Dabigatran etexilate mesylate HPLC ≥99.0% light yellow solid Single impurity ≤0.5% Loss on drying ≤1.0% Residue on ignition ≤0.1% Heavy melta ≤20 ppm Assay ≥98.5%
Taizhou Volsen Chemical Co., Ltd. is professional in R&D, producing and marketing Pharmaceutical raw materials, pharmaceutical intermediates in China. VOLSEN consists of about 100 experienced employees including 3 PhD and 10 Master, and 35000 sqm facilities including research laboratories, kilo lab, pilot plant and full manufacturing plant,
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- Company Name: Taizhou Volsen Chemical Co., Ltd.
- Representative: Mr Chen
- Product/Service: Efinaconazole Intermediates , Isavuconazole Intermediates , Obeticholic Acid Intermediates , Vilanterol Intermediates , Dolutegravir Intermediates , Umeclidinium Bromide
- Capital (Million US $): 60000000RMB
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- No. of Production Lines: 5
- No. of R&D Staff: 91 -100 People
- No. of QC Staff: 11 -20 People
- OEM Services Provided: yes
- Factory Size (Sq.meters): 30,000-50,000 square meters
- Factory Location: Dongying Economic Development Zone , Dongying, Shandong,China
- Contact Person: Ms. Amy Cheng
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